Research progress in the role of irisin in tumors
10.3781/j.issn.1000-7431.2017.55.099
- Author:
Deguo ZHANG
1
Author Information
1. Qingdao Municipal Hospital Affiliated to Qingdao College
- Publication Type:Journal Article
- Keywords:
Diagnosis;
Irisin;
Molecular;
Molecular targeted therapy;
Neoplasms;
Pathology
- From:
Tumor
2017;37(5):524-529
- CountryChina
- Language:Chinese
-
Abstract:
Irisin, a newly discovered cytokine induced by exercises, is proteolytically cleaved from fibronectin type ? domain-containing 5 (FNDC5). Irisin is widely distributed and has the functions including browning white adipose tissues, ameliorating insulin resistance and improving cognition. However, the latest studies have found that irisin is closely associated with the occurrence and development of various tumors, suggesting that irisin may be a potential target for tumor diagnosis and treatment. Therefore, it is significant to study the relationship between irisin and tumors for the prevention and treatment of tumor. This paper summarizes the progress in the role of irisin in tumors.
