Progress in treatment of colorectal cancer with K-Ras gene mutation
10.3781/j.issn.1000-7431.2017.55.615
- Author:
Yanhong PAN
1
Author Information
1. School of Pharmacy, Nanjing University of Chinese Medicine
- Publication Type:Journal Article
- Keywords:
Antineoplastic combined chemotherapy protocols;
Colorectal neoplasms;
Drug resistance;
Genes;
Neoplasm;
Ras
- From:
Tumor
2017;37(4):412-418
- CountryChina
- Language:Chinese
-
Abstract:
Colorectal cancer is currently one of the carcinomas with highmortality in the world, and its incidence is increasing year by year. In the course of treatment, the patients with colorectal cancer prone to metastasis and recurrence because of the presence of v-Kiras2 Kirsten rat sarcoma viral oncogene homolog (K -Ras) gene mutations, which seriously limits the treatment of colorectal cancer. Drug resistance is a major problem in oncotherapy, which is more prominent in the treatment of K -Ras -mutated colorectal cancer, and the effective treatment strategies are still lacked in present. With the increase of reports about the formation mechanisms of drug resistance, recurrence and metastasis, as well as the discovery of molecular biomarkers in colorectal cancer with K -Ras gene mutations, the new drugs and the corresponding combination regimens appear constantly. Furthermore, the therapy of K -Ras -mutated colorectal cancer is more rational, but there are still many problems. Therefore, this paper focuses on the lasted studies on colorectal cancer with K -Ras -mutations, and reviews the progress in K -Ras mutation characteristics, treatment difficulties and research breakthroughs as well as the future prediction, hoping to provide some useful references for the subsequent clinical treatment and research.
