Expression of SET8 protein in renal clear cell carcinoma and its clinical significance
10.3781/j.issn.1000-7431.2017.33.293
- Author:
Shaohui GAO
1
Author Information
1. Department of Nephrology, Fourth Hospital of Hebei Medical University
- Publication Type:Journal Article
- Keywords:
Immunohistochemistry;
Kidney neoplasms;
Methyltransferases;
Prognosis;
SET8 protein
- From:
Tumor
2017;37(10):1063-1068
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the relationship between the expression of histone lysine methyltransferase SET8 protein and the prognosis of renal clear cell carcinoma. Methods: All of 100 patients with renal clear cell carcinoma who were confirmed by pathology and received nephrectomy in Fourth Hospital of Hebei Medical University from January 2008 to January 2012 were selected. The expression of SET8 protein in renal clear cell carcinoma tissues was detected by immunohistochemical mehtod. The correlation of SET8 protein expression rate with the clinicopathological characteristics (gender, year, TNM stage, tumor size and lymph node metastasis) and five-year survival rate of patients with renal clear cell carcinoma were analyzed. Results: The high expression rate of SET8 protein was 46.00% (46/100) in renal clear cell carcinoma tissues, and its expression was closely associated with tumor diameter and lymph node metastasis (both P < 0.05). Univariate analysis by log-rank test showed that the five-year survival rate was closely associated with TNM staging, tumor diameter, lymph node metastasis and SET8 protein expression (all P < 0.05). Multivariate analysis with COX proportional hazards model showed that tumor diameter > 5 cm and the high expression of SET8 protein could increase the death risk of patients with renal clear cell carcinoma by 6.122 and 4.762 times, respectively (both P < 0.05). Conclusion: The high expression of SET8 protein is closely related to tumor diameter and lymph node metastasis of renal clear cell carcinoma, and it is an independent risk factor for the prognosis of patients with renal clear cell carcinoma.
