Correlation of SDF-1 and CXCR4 expressions and MVD with the prognosis of multiple myeloma
10.3781/j.issn.1000-7431.2017.33.621
- Author:
Fanli LIN
1
Author Information
1. Department of Hematology, Affiliated Hospital of Southwest Medical University
- Publication Type:Journal Article
- Keywords:
Chemotactic factors;
Microvessel density;
Multiple myeloma;
Prognosis
- From:
Tumor
2017;37(11):1179-1187
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the expressions of stromal cell-derived factor-1 (SDF-1) and its receptor chemokine (C-X-C motif) receptor 4 (CXCR4) as well as the microvessel density (MVD) in patients with multiple myeloma, and to explore their effects on the prognosis. Methods: The expressions of SDF-1 and CXCR4 as well as MVD in bone marrow fr o m 7 8 p ati e n ts wi thmul tiple m yelom a an d 3 0 norm alperson s wered e te ctedby immunohistochemical method. The correlations of age, gender, international staging system (ISS) staging, immunoglobulin typing, light chain classification, SDF-1 expression, CXCR4 expression and MVD with the prognosis of multiple myeloma patients were analyzed. Results: The expression of SDF-1 in bone marrow of multiple myeloma patients was positively cor re lated wi th th e exp ressionof CXCR4 and the count of MVD (b oth P < 0. 0 1 ). The expression levels of SDF-1 and CXCR4 as well as the count of MVD were not correlated with the induction therapy in patients with multiple myeloma (all P > 0.05). The overall survival rate and progression-free survival rate of multiple myeloma patients with low expressions of SDF-1 and CXCR4 were lower than those of patients with high expressions of SDF-1 and CXCR4 (both P < 0.05). The overall survival rate and progression-free survival rate of patients with multiple myeloma in low count of MVD group were higher than those in the high count of MVD group (both P < 0.05). The age, SDF-1 and CXCR4 expressions, and MVD were independent prognostic factors for the patients with multiple myeloma (all P < 0.05). Conclusion: The expressions of SDF-1 and CXCR4 and the count of MVD were independent prognostic factors for the patients with multiple myeloma. SDF-1, CXCR4 and MVD may play promoting roles in the malignant progression of multiple myeloma, so they are expected to become new targets for the treatment of multiple myeloma in the future.
