Research progress in miR-138 in tumors
10.3781/j.issn.1000-7431.2017.44.357
- Author:
Mingjia CHENG
1
Author Information
1. Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, National Clinical Research Center of Stomatology
- Publication Type:Journal Article
- Keywords:
Carcinogenesis;
MicroRNAs;
miR-138;
Neoplasms;
Prognosis
- From:
Tumor
2017;37(12):1334-1338
- CountryChina
- Language:Chinese
-
Abstract:
microRNA (miRNA, miR) has attracted great interest in recent years. miR-138 is closely related to the occurrence, development and prognosis of different kinds of malignant tumors.Present studies have shown that miR-138 is frequently down-regulated in tumor cells and tissues. Down-regulation expression of miR-138 can promote the proliferation, invasion and metastasis in a variety of malignant tumor cells. Up-regulation expression of miR-138 may play a crucial role in tumor suppression, and enhance sensitivity of tumor cells to radiotherapy and chemotherapy. Therefore, miR-138 can be considered as a biomarker of tumor prognosis, and also one of the tumor therapeutic targets.
