Evolutionary patterns and influencing factors of tumor cell subclones
10.3781/j.issn.1000-7431.2018.55.470
- Author:
Pengyan XU
1
Author Information
1. Department of Oncology, Harbin Medical University, Cancer Hospital
- Publication Type:Journal Article
- Keywords:
Neoplasm metastasis;
Neoplasms;
Subclone;
Tumor microenvironment
- From:
Tumor
2018;38(3):278-282
- CountryChina
- Language:Chinese
-
Abstract:
Tumor cells have genetic instability, which ultimately leads to the production of different tumor cells with different gene mutations and different subclone manifestations. The coexistence mechanism and biological consequences of different subclones are extremely complex. Tumor cell subclones can carry out linear or branching evolution under different selection pressures. Tumor microenvironment is one of important selection pressures, which not only affects the evolution of tumor subclones, but also affects the growth of subclones and their interaction more widely. Tumor metastasis is a major reason for the poor prognosis of tumor patients. The low-frequency subclones in original tumor cells play an important role in the process of tumor metastasis. What subtle changes in tumor cells can make the transition of low-frequency subclones? It has become the focus of current study. This review focuses on the evolutionary patterns and influencing factors of tumor cell subclones in order to understand the subclones for guiding the clinical individual treatment.
