Effects of tumor microenvironment on tumor angiogenesis
10.3781/j.issn.1000-7431.2018.55.764
- Author:
Dongyu WANG
1
Author Information
1. Department of Pathophysiology, Basic Medical College, Zhengzhou University
- Publication Type:Journal Article
- Keywords:
Endothelial cells;
Extracellular matrix;
Fibroblasts;
Immune cells;
Neovascularization;
Pathologic;
Pericytes;
Tumor microenvironment
- From:
Tumor
2018;38(4):379-385
- CountryChina
- Language:Chinese
-
Abstract:
The tumor microenvironment is a dynamic network, which includes various types of cells (such as tumor cells, vascular endothelial cells, fibroblasts, immune cells, and pericytes) and extracellular components (such as cytokines, growth factors, and extracellular matrix). The impact of tumor microenvironment on the development of tumor is becoming more and more attractive. Tumor angiogenesis is a hallmarker in growth, invasion and metastasis of solid tumor. More and more studies show that tumor angiogenesis is closely related to tumor microenvironment, but the precise mechanism is still unclear. In this review, the effect of tumor microenvironment on tumor angiogenesis is analyzed in detail, so as to provide a broader thinking for anti-tumor angiogenesis research.
