Advances in role of radiation sensitivity regulated by telomerase in cancer therapy
10.3781/j.issn.1000-7431.2018.55.599
- Author:
Xiangxuan ZHAO
1
Author Information
1. Department of Radiology, Shengjing Hospital, China Medical University
- Publication Type:Journal Article
- Keywords:
DNA damage;
Neoplasms;
Radiotherapy;
Signaling pathway;
Telomerase
- From:
Tumor
2018;38(5):498-501
- CountryChina
- Language:Chinese
-
Abstract:
Ionizing radiation (IR) including X-ray and X-ray can induce apoptosis of cancer cells, mainly due to telomere damage and genome DNA breaks caused by IR. Although IR has been used clinically to cure some types of malignant tumors, the inherent or acquired resistance of cancer cells to IR has increasingly been an impediment for its usage. Overwhelming evidence has shown that telomerase is able to repair IR-induced telomere and chromosome damages, which may play key roles in mediating IR resistance. Unfortunately, the underlying mechanisms remain poorly known. This paper reviews the advances in research on telomerase-mediated regulation of IR sensitivity in recent 10 years, in order to clarify the molecular mechanism and the roles of telomerase-mediated regulation of IR sensitivity in cancer therapy and hope to provide useful clues and instructions for IR in cancer therapy.
