Long non-coding RNA in malignant melanoma
10.3781/j.issn.1000-7431.2018.55.042
- Author:
Haipeng WEI
1
Author Information
1. Department of Dermatology & Sexually Transmitted Disease (STD), Beihai Peoples Hospital
- Publication Type:Journal Article
- Keywords:
Gene expression;
Long non-coding;
Melanoma;
Molecular mechanism;
RNA;
Skin neoplasms
- From:
Tumor
2018;38(10):992-1000
- CountryChina
- Language:Chinese
-
Abstract:
Malignant melanoma is the leading cause of skin cancer-related deaths. However, the current understanding of molecular mechanism for malignant melanoma remains extremely limited, and the therapeutic methods of malignant melanoma need to be broken urgently. Long non-coding RNA (LncRNA) regulates gene expression as RNA molecules at many levels, including epigenetic regulation, transcriptional regulation and post- transcriptional regulation. In recent years, with the in-depth research of LncRNA, it is showed that LncRNA molecules have a strong correlation with the occurrence of many major human diseases, including malignant melanoma. Many LncRNAs associated with malignant melanoma have been found, and the molecular mechanisms of some LncRNAs involving the proliferation, invasion and metastasis of malignant melanoma cells have been gradually discovered. So the research of LncRNAs on the early diagnosis and treatment of malignant melanoma as well as the development of target drugs has become a hotspot. In this article, the research progress in LncRNAs associated with malignant melanoma is emphatically reviewed, and their potential value in clinical application for malignant melanoma is preliminarily discussed.
