Correlation of18F-FDG PET/CT SUVmax value with clinical parameters and biological indicators in patients with lymphoma
10.3781/j.issn.1000-7431.2018.33.235
- Author:
Lingfang ZHANG
1
Author Information
1. Department of Oncology, Gansu Provincial Hospital
- Publication Type:Journal Article
- Keywords:
Erythrocyte sedimentation rate;
Fluorine-18-fludeoxyglucose;
Lactate dehydrogenases;
Lymphoma;
Positron emission tomography/ computed tomography;
Standard uptake value
- From:
Tumor
2018;38(12):1143-1149
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To evaluate the application value of fluorine-18-fludeoxyglucose (18F-FDG) PET/CT maximal standard uptake (SUVmax) in the diagnosis of lymphoma. Methods: A total of 103 patients with lymphoma which confirmed by pathological diagnosis in Gansu Provincial Hospital from January 2011 to December 2016 were collected. All patients underwent a whole body simultaneous18F-FDG PET/CT and had complete clinical data. The possible relationships of SUVmax with the different pathological subtypes, clinical stages and risk grades of lymphoma were analyzed. The correlations of SUVmax value with Ki-67 index, lactate dehydrogenase (LDH) and erythrocyte sedimentation rate (ESR) were analyzed. Results: There was no significant difference in SUVmax between Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL) (P > 0.05). The SUVmax in patients with strongly invasive diffuse large B-cell lymphoma (DLBCL), T-lymphoblastic lymphoma (T-LBL), anaplastic large cell lymphoma (ALCL) and natural killer (NK)/T cell lymphoma was higher than that in patients with relatively weakly invasive mantle cell lymphoma (MCL), peripheral T-cell lymphoma (PTCL), small lymphocytic lymphoma (SLL), follicular lymphoma (FL) (grade 1-2) and marginal zone lymphoma (MZL) (P < 0.05). The SUVmax in the patients with DLBCL was higher than that in the patients with MCL, PTCL, SLL, FL and MZL, respectively (all P < 0.05). The SUVmax in the patients with ALCL was higher than that in the patients with FL (P < 0.05). The differences of SUVmax among other subtypes were not statistically significant (P > 0.05). The SUVmax had no significant difference between stage -Ⅱ and III- in the patients with lymphoma (P > 0.05). The SUVmax in the patients with high-risk NHL was higher than that in the patients with intermediate- and low-risk NHL (both P < 0.01). For 103 patients with lymphoma, the SUVmax obviously had a positive correlation with Ki-67 index (r = 0.67, P < 0.001). There was no significant difference in SUVmax between the ESR increasing group and the normal group as well as between the LDH increasing group and the normal group (both P > 0.05). Conclusion:18F-FDG PET/CT SUVmax can be used as a reference indicator for evaluating the invasive degree of lymphoma, predicting Ki-67 index, and judging the risk classification of NHL.
