Progress in molecular mechanisms of breast cancer bone metastasis
10.3781/j.issn.1000-7431.2019.55.859
- Author:
Mingxi LIN
1
Author Information
1. Department of Medical Oncology, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University
- Publication Type:Journal Article
- Keywords:
Breast neoplasms;
Clinical study;
Estrogen receptor;
Neoplasm metastasis;
Tumor microenvironment
- From:
Tumor
2019;39(9):767-774
- CountryChina
- Language:Chinese
-
Abstract:
Bone metastasis is common for advanced breast cancer, and can cause pathologic fractures, hypercalcemia, spinal cord compression and other skeletal-related events. The life quality of patients with bone metastasis will be seriously affected. But for now, the mechanism of breast cancer bone metastasis is not clear. As a result, there are no effective and targeted treatments, except the locoregional therapy such as radiation therapy and surgery. Therefore, this review focuses on the molecular mechanisms of breast cancer bone metastasis in order to lay a foundation for further research of effective targeted therapy. Firstly, in this review, a complex succession of invasion-metastasis cascade in bone metastasis is expounded, and the positive feedback “vicious cycle” promoting the milignant proliferation of tumor cells is expatiated. Then the estrogen receptor mediating mechanism of bone metastasis is discussed. In the end, the recent advances in clinical research of breast cancer bone metastasis and the forward future research directions are summarized.
