Progress of exosome in the diagnosis and treatment of brain metastasis of breast cancer
10.3781/j.issn.1000-7431.2020.55.385
- Author:
Jiao LUO
1
Author Information
1. Department of Oncology and Hematology, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital
- Publication Type:Journal Article
- Keywords:
Brain metastases;
Breast neoplasms;
Exosomes;
LncRNA;
MicroRNA
- From:
Tumor
2020;40(5):361-370
- CountryChina
- Language:Chinese
-
Abstract:
Breast cancer is the most common malignant tumor about women in China, and brain metastasis may occur in about 5% to 20% of breast cancer patients. Exosome is a kind of vesicle secreted into the extracellular environment. In the recent years’ study, it has been found that exosome may participate in the occurrence and development of brain metastasis, thus they can be regarded as the diagnosis of breast cancer brain metastasis potential biomarker, and play important roles in the drug delivery carrier. Also, they serve as therapeutic target in the treatment of breast cancer. Therefore, this review focuses on the role of exosome in the diagnosis and treatment of breast cancer brain metastasis in order to provide potential biomarkers, such as protein and RNA, and lay a foundation for further research of effective targeted therapeutic.
