Changes in serum levels of fibroblast growth factor-2, hypoxia-inducible factor-1alpha and vascular endothelial growth factor in patients with avascular necrosis of femoral head treated by enriched autologous bone marrow stem cell transplantation combined with core decompression
10.3969/j.issn.2095-4344.2002
- Author:
Jingyi ZHANG
1
Author Information
1. Zhengzhou Orthopedics Hospital
- Publication Type:Journal Article
- Keywords:
Avascular necrosis of femoral head;
Core decompression;
Fibroblast growth factor-2;
Hypoxia-inducible factor-1α;
Stem cell transplantation;
Vascular endothelial growth factor
- From:
Chinese Journal of Tissue Engineering Research
2020;24(1):14-19
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND: Avascular necrosis of the femoral head is mainly caused by insufficient blood supply of the femoral head. Core decompression is a common clinical treatment, enriched autologous bone marrow stem cell transplantation can improve hip function, and combined application can promote early recovery of patients. OBJECTIVE: To investigate the therapeutic effects of enriched autologous bone marrow stem cell transplantation combined with core decompression on serum levels of fibroblast growth factor-2, hypoxia-inducible factor-1α and vascular endothelial growth factor in patients with early avascular necrosis of femoral head. METHODS: Sixty-two cases of early avascular necrosis of femoral head treated from January 2016 to January 2018 were selected, and were divided into study group (n=31) and control group (n=31) according to the random number table method. The control group was treated with fine-needle porous-channel core pulp decompression, while the study group was treated with enriched autologous bone marrow stem cell transplantation on the basis of the control group. Harris score, Visual Analogue Scale score, serum fibroblast growth factor-2, hypoxia-inducible factor-1α and vascular endothelial growth factor levels and adverse reactions were observed before and after treatment. RESULTS AND CONCLUSION: (1) The Harris scores at 3, 6 and 12 months after treatment in the two groups were higher than those before treatment (P < 0.05), and those in the study group were higher than those in the control group (P < 0.05). (2) The Visual Analogue Scale scores at 3, 6 and 12 months after treatment in the two groups were lower than those before treatment (P < 0.05), and the scores at 3 and 6 months after treatment in the study group were lower than those in the control group (P < 0.05). (3) The levels of serum fibroblast growth factor-2 at 3, 6 and 12 months in the two groups were higher than those before treatment, and the scores in the study group were higher than those in the control group (P < 0.05). The levels of hypoxia-inducible factor-1α and vascular endothelial growth factor in the two groups were significantly lower than those before treatment (P < 0.05), and those in the study group were lower than those in the control group (P < 0.05). (4) There was no significant difference in the incidence of adverse reactions between two groups after treatment (P > 0.05). (5) These results suggest that enriched autologous bone marrow stem cell transplantation combined with core decompression in the treatment of early avascular necrosis of femoral head can effectively improve hip joint function, promote the repair of femoral head necrosis area, alleviate pain, increase the level of fibroblast growth factor-2, and reduce the levels of hypoxia-inducible factor-1α and vascular endothelial growth factor.
