Pathogenesis of inflammatory bowel disease and mesenchymal stem cell therapy: Therapeutic application and existing problems
10.3969/j.issn.2095-4344.1846
- Author:
Wenwen HUANG
1
Author Information
1. Yan’an Hospital affiliated to Kunming Medical University
- Publication Type:Journal Article
- Keywords:
Crohn’s disease;
Immune regulation;
Inflammatory bowel disease;
Mesenchymal stem cells;
Ulcerative colitis
- From:
Chinese Journal of Tissue Engineering Research
2020;24(7):1138-1143
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND: In recent years, the incidence of inflammatory bowel disease is yearly increasing, and there are no effective treatment plans. Mesenchymal stem cells have achieved good outcomes in the treatment of immune-related diseases such as systemic lupus erythematosus, myocardial infarction and graft-versus-host disease. Numerous studies have shown that mesenchymal stem cells have their unique advantages in thetreatment of inflammatory bowel disease. Therefore, increasing concern has been placed on the treatment of inflammatory bowel disease by mesenchymal stem cells. OBJECTIVE: To summarize the existing research on the treatment of inflammatory bowel disease by mesenchymal stem cells, and to discuss its application and safety. METHODS: “Mesenchymal stem cells, inflammatory bowel disease, pathogenesis, treatment” were used as keywords to search CNKI, WanFang and PubMed databases for relevant literatures in the past 20 years both in Chinese and English. Finally, 62 papers were selected for review. RESULTS AND CONCLUSION: Mesenchymal stem cells have the abilities of self-renewal, tissue migration and pluripotency, as well as strong immunomodulatory effects. They not only show satisfying therapeutic effects in systemic lupus erythematosus, myocardial infarction, graft-versus-host disease and other immune-related diseases, but also have promising prospects in inflammatory bowel disease. However, little is reported in clinical studies, and there are still many problems, such as safety, encountered in the treatment of inflammatory bowel disease with mesenchymal stem cells.
