Application and prospect of bone marrow mesenchymal stem cells in the treatment of early femoral head necrosis
10.3969/j.issn.2095-4344.1863
- Author:
Tiantian WANG
1
Author Information
1. Inner Mongolia Medical University
- Publication Type:Journal Article
- Keywords:
Bone marrow mesenchymal stem cells;
Core decompression;
Osteonecrosis of the femoral head;
Review;
Tissue engineering
- From:
Chinese Journal of Tissue Engineering Research
2020;24(7):1117-1122
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND: Femoral head necrosis is a common progressive disabling disease in orthopedics, and it is difficult to reverse disease progression. Eventually, the loss of hip function seriously impact patient’s quality of life. OBJECTIVE: To review the research progress of bone marrow mesenchymal stem cells in the treatment of femoral head necrosis. METHODS: The PubMed, CNKI and WanFang databases were searched for relevant articles with the keywords of “bone marrow mesenchymal stem cells, femoral head necrosis” in English and Chinese, respectively. The search time was from January 2001 to April 2019. Articles that were not related to the purpose of the research and repetitive articles were excluded, and 42 articles that met the criteria were finally included for review. RESULTS AND CONCLUSION: Bone marrow mesenchymal stem cells potentially repair the femoral head,not only providing precursor cells, but also secreting cytokines and growth factors and initiating cell healing in thefemoral head. A large number of experimental and clinical studies have proved that bone marrow mesenchymal stem cells are available for the treatment of early femoral head necrosis.
