Diverse VacA Allelic Types of Helicobacter pylori in Korea and Clinical Correlation.
10.3349/ymj.2002.43.3.351
- Author:
Yon Ho CHOE
1
;
Pum Soo KIM
;
Don Haeng LEE
;
Hyung Kil KIM
;
Young Soo KIM
;
Yong Woon SHIN
;
Tae Sook HWANG
;
Hyeon Joo KIM
;
Sun Uk SONG
;
Mi Sook CHOI
Author Information
1. Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Helicobacter pylori;
vacA;
allele;
signal sequence;
mid-region
- MeSH:
Adolescent;
Adult;
Aged;
Aged, 80 and over;
*Alleles;
Amino Acid Sequence/genetics;
Bacterial Proteins/*genetics/metabolism;
Child;
Helicobacter Infections/physiopathology/virology;
Helicobacter pylori/*genetics;
Human;
Korea;
Middle Age;
Molecular Sequence Data
- From:Yonsei Medical Journal
2002;43(3):351-356
- CountryRepublic of Korea
- Language:English
-
Abstract:
Helicobacter pylori has a diversity of vacA allelic types. The purpose of this study was to correlate the vacA status and the clinical outcome. After constructing specific primers for the vacA signal sequence, H. pylori-positive antral biopsy specimens were examined for the vacA status in 25 gastric ulcers, 31 duodenal ulcers, 22 gastric cancers, 42 chronic gastritis, and 8 gastroduodenal ulcers. The relationship between the vacA allele and the clinical disease was examined. The vacA genotype s1c/m1 is predominant in Korea (71/128, 55.5%). Other strains including s1b or s2 were not found in this study. s1c/m1 was more prominent in duodenal ulcers, than in gastric ulcers (p=0.041) and cancer (p=0.029). Seven out of 8 patients with gastric and coexistent duodenal ulcers had the s1c/m1 allele. No statistical differences in the positive rates of the s1a/m1, s1a/m2, and s1c/m2 alleles among the disease groups were found. In conclusion, s1c/m1 is the main vacA allele in Korea and it is particularly associated with duodenal ulcers.
