Selection of animal models of osteoarthritis
10.3969/j.issn.2095-4344-1995
- Author:
Xiaochen LIU
1
Author Information
1. West China School of Medicine, Sichuan University
- Publication Type:Journal Article
- Keywords:
Animals;
Dogs;
Guinea pigs;
Mice;
Models;
Osteoarthritis;
Rabbits;
Rats
- From:
Chinese Journal of Tissue Engineering Research
2020;24(11):1769-1776
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND: The pathogenesis of osteoarthritis is unknown, and there is no effective treatment. Selecting appropriate animal models will create a good condition for animal experiments on osteoarthritis. OBJECTIVE: To review different experimental animals of osteoarthritis and different modeling methods. METHODS: CNKI, WanFang, VIP and PubMed databases were searched for the articles published from January 2013 to July 2018. The keywords were “osteoarthritis, models, animals, mice, rats, goats, guinea pigs, sheep” in Chinese and English, respectively. The repetitive articles were excluded, and the articles related to osteoarthritis and animal models were selected for summary and result analysis. RESULTS AND CONCLUSION: Mice, rats, guinea pigs, rabbits, dogs, sheep and other animals can be used as animal models for osteoarthritis research. When studying animal models of osteoarthritis, it is important to choose the right animal models and construction methods. Non-surgical models will not make damage to the parts except for joints, which is in accordance with the pathological process of osteoarthritis. But it is difficult to control, thus causing errors, and it cannot simulate traumatic changes. Surgical models induce joint injury by tissue damage, which exhibits advantages in rapid disease progress and obvious outcomes. Therefore, surgical models are optimal choice for short-term experiments. Different experimental animals and modeling schemes have their own advantages and disadvantages, which need to be reasonably selected according to the requirements of experiments.
