Research progress in the treatment of spinal cord injury with mesenchymal stem cell secretome
10.3969/j.issn.2095-4344.2113
- Author:
Ran WAN
1
Author Information
1. Department of Orthopedics, the First Affiliated Hospital of Harbin Medical University
- Publication Type:Journal Article
- Keywords:
Cell-free treatment;
Mesenchymal stem cell secretome;
Nerve regeneration;
Review;
Spinal cord injury
- From:
Chinese Journal of Tissue Engineering Research
2020;25(7):1088-1095
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND: Spinal cord injury often leads to patients’ permanent sensory, motor and autonomic dysfunction because of limited inherent regeneration capacity of the central nervous system. Spinal cord injury seriously affects patients’ quality of life but there is still no effective treatment for it. The existing studies suggest that mesenchymal stem cell secretome mediates the main therapeutic effect of cell transplantation and avoids problems such as cellular rejection, so it will become a powerful tool for the treatment of spinal cord injury. OBJECTIVE: To summarize the research progress of mesenchymal stem cell secretome in the treatment of spinal cord injury, and analyze the current problems and future development direction. METHODS: The PubMed database was retrieved with “spinal cord injury, secretome” as the keywords, and Chinese databases include CNKI and Wanfang were retrieved with “spinal cord injury, secretome” as the keywords in Chinese. We retrieved the articles published from January 2013 to January 2020 and excluded the articles that were irrelevant or repetitive. At last 71 articles that met the criteria were included for review. RESULTS AND CONCLUSION: The mesenchymal stem cell secretome is rich in extracellular vesicles and soluble molecules such as growth factors and neurotrophic factors, and it plays prominent place in reducing cell apoptosis, regulating immune response, inhibiting scar formation, promoting nerve regeneration and angiogenesis. Numerous studies have shown that the mesenchymal stem cell secretome can promote nerve regeneration and function recovery after spinal cord injury, and it avoids the disadvantages of cell transplantation. The mesenchymal stem cell secretome will become a reliable method to treat spinal cord injury in the future.
