Extracellular matrix and tissue engineering regeneration and repair
10.3969/j.issn.2095-4344.3100
- Author:
Yaxin LUO
1
Author Information
1. Department of Periodontology, Stomatological Hospital Affiliated to Zunyi Medical University
- Publication Type:Journal Article
- Keywords:
Biomaterial;
Defect;
Extracellular matrix;
Material;
Regeneration;
Review;
Tissue engineering
- From:
Chinese Journal of Tissue Engineering Research
2020;25(11):1785-1790
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND: Extracellular matrix can provide a living environment for different types of cells in the body and affect their biological activities, playing an important role in maintaining cell homeostasis and tissue development. OBJECTIVE: To review the research progress of extracellular matrix and its application in tissue engineering regeneration. METHODS: Databases of PubMed and CNKI were retrieved with the key words of “extracellular matrix, tissue engineering, regeneration” in English and Chinese search from 2010 to 2020, respectively. RESULTS AND CONCLUSION: The extracellular matrix contains a variety of components, and its extraction methods are diverse. It has many functions, such as guiding cells, transmitting signals, diagnosing and treating diseases, regenerating and repairing. As a precise and orderly network structure, extracellular matrix has unique advantages in tissue regeneration and repair. Extracellular matrix provides a microenvironment closest to the growth of cells in vivo, and it is rich in various active molecules, which can provide the basis for cell activity, and has a good application prospect. The forms of extracellular matrix existing in tissue regeneration are varied, and it has good biodegradability and low immunogenicity, which can also improve the inflammatory response to a certain extent, can support tissue regeneration and guide tissue reconstruction effectively. With the continuous in-depth study to extracellular matrix, its application in tissue engineering will be better developed, and it will also bring emerging technologies and treatment methods for regenerative medicine and tissue engineering in the future. However, as for the problems faced by extracellular matrix in tissue repair applications, further research and discussion are needed.
