Application of mineralized collagen modified bone cement in the treatment of osteoporotic vertebral compression fractures
10.3969/j.issn.2095-4344.2603
- Author:
Wenkang JIANG
1
Author Information
1. Shandong First Medical University and Shandong Academy of Medical Sciences
- Publication Type:Journal Article
- Keywords:
Adjacent vertebral fracture;
Bone cement;
Mineralized collagen;
Osteoporosis;
Percutaneous vertebroplasty;
Vertebral compression fracture
- From:
Chinese Journal of Tissue Engineering Research
2020;24(15):2381-2386
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND: Simple bone cement is easy to cause refracture of adjacent vertebra due to its high hardness. Currently, a material that can reduce the incidence of adjacent vertebra fracture is urgently needed. OBJECTIVE: To observe the clinical efficacy of percutaneous vertebroplasty using mineralized collagen modified bone cement. METHODS: Totally 60 patients with fresh single osteoporotic vertebral compression fractures who underwent percutaneous vertebroplasty were randomly divided into two groups, with 30 cases in each group. Patients in the simple bone cement group were given polymethyl methacrylate bone cement. Patients in the modified bone cement group were given mineralized collagen modified bone cement mixed with artificial bone repair material and simple polymethyl methacrylate bone cement. All patients signed the informed consent. This study was approved by the Hospital Ethics Committee. The follow-up time was 6-12 months. The clinical effect was assessed by the visual analogue scale, Oswestry Disability Index, Cobb angle and percentage of vertebral anterior edge height before surgery, at 2 days after surgery and during the last follow-up. Postoperative complications were recorded. RESULTS AND CONCLUSION: (1) All patients underwent successful operation. A total of four patients were found to have different degrees of bone cement leakage, and none of the patients presented obvious clinical discomfort symptoms. (2) Compared with pre-operation, visual analogue scale and Oswestry Disability Index were significantly improved (P < 0.05); the height of the anterior border of the injured vertebrae and the Cobb angle of the kyphosis were not significantly changed (P > 0.05) at 2 days after operation and during the last follow-up in the two groups. There were no significant differences in above indexes between the two groups at the same time point (P > 0.05). (3) The number of adjacent fractures in the simple bone cement group was more than that in the modified bone cement group, but there was no statistically significant difference in the incidence of adjacent vertebral fractures between the two groups (P > 0.05). (4) It is confirmed that compared with simple bone cement, mineralized collagen modified bone cement has no obvious disadvantages. In addition, mineralized collagen modified bone cement can give better biological properties while ensuring the strength of bone cement support and reducing pain. Further studies are needed to reduce the incidence of adjacent vertebral fractures.
