Macrophages can regulate bone homeostasis and erythropoiesis: Problems and prospects
10.3969/j.issn.2095-4344.2669
- Author:
Xing WEI
1
Author Information
1. Department of Orthopedics, Taikang Xianlin Drum Tower Hospital, Nanjing University School of Medicine
- Publication Type:Journal Article
- Keywords:
Bone homeostasis;
Erythropoiesis;
Erythropoietin;
Macrophage;
Osteogenesis
- From:
Chinese Journal of Tissue Engineering Research
2020;24(18):2926-2931
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND: Regulation of erythropoiesis in the bone marrow microenvironment is a carefully orchestrated process dependent upon systemic and local cues. Systemic erythropoietin production by renal interstitial cells plays a critical role in maintaining erythropoietic homeostasis. Increasing evidences have shown that erythropoietin and erythropoiesis can alter skeletal homeostasis, suggesting a functional relationship between the regulation of erythropoiesis and bone homeostasis. In recent years, macrophages play a regulatory role in erythropoietin, bone homeostasis and erythropoiesis. OBJECTIVE: To summarize the research advance concerning the role of macrophages in erythropoiesis and bone homeostasis. METHODS: PubMed, Medline, Web of Science, Wanfang and CNKI databases were retrieved with the keywords of “erythropoiesis, macrophage, erythropoietin, bone formation, bone homeostasis” in English and Chinese, respectively for relevant articles published from January 1999 to October 2019. Finally 48 articles eligible for inclusion and exclusion criteria were included for further analysis. RESULTS AND CONCLUSION: As key local components of the bone marrow microenvironment and erythropoietic niche, macrophage subsets play important roles in both processes. Peritoneum macrophages, glial macrophages and liver resident macrophages promote the production of erythropoietin in renal interstitium. Bone marrow macrophages or osteoma, osteoclasts and central macrophages regulate bone homeostasis, and further promote erythropoiesis.
