Potentials of pericytes in orthopedics
10.3969/j.issn.2095-4344.2036
- Author:
Mingchuan YU
1
Author Information
1. Department of Orthopedics, The Second Affiliated Hospital of Nanchang University
- Publication Type:Journal Article
- Keywords:
Bone tissue engineering;
Cell transplantation;
Mesenchymal stem cells;
Pericytes;
Perivascular cells;
Regenerative medicine
- From:
Chinese Journal of Tissue Engineering Research
2020;24(19):3078-3083
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND: Pericytes and other perivascular stem cells are gaining increasing attention in bone tissue engineering. Pericytes have been long thought to regulate blood pressure and promote angiogenesis. However, it is now considered to have the characteristics of mesenchymal stem cells, including pluripotency, self-renewal, immune regulation, and tissue repair, showing strong regenerative potential in common orthopedic diseases such as fractures, nonunion, vertebral fusion, ligament rupture, and cartilage injury. OBJECTIVE: To summarize the related applications of pericytes in orthopedics, and to explore mechanisms, strengths and limitations.METHODS: With “pericytes, perivascular stem cells, repair, therapy, orthopedics” as Chinese and English retrieval terms, we systematically searched databases including PubMed, Web of Science, CNKI and WanFang, from inception to August 2019 for the articles concerning the treatment of orthopedic diseases with pericytes. A total of 112 related documents were retrieved. After reading the full text, 55 eligible documents were selected. RESULTS AND CONCLUSION: Pericytes are a kind of emerging stem cells that have been reported in many studies regarding the treatment of orthopedic diseases, and have a greatly therapeutic prospect. There are abundant pericytes in the body with no need for in vitro culture. The repair mechanism of pericytes is mainly related to paracrine mediation, with self-differentiation as a secondary mechanism. However, its specific mechanism remains unclear, which needs further investigations.
