Immunohistochemical Identification of Keratin in Cutaneous Tumors.
- Author:
Kwang Youl LEE
;
Youn Hong CHOI
;
Kyu Cherl CHO
- Publication Type:Original Article
- Keywords:
Keratin;
Cutaneous tumors;
Avidin - biotin - peroxidase complex
- MeSH:
Animals;
Bowen's Disease;
Carcinoma, Basal Cell;
Carcinoma, Squamous Cell;
Hemangioma;
Histiocytoma, Benign Fibrous;
Horns;
Keratoacanthoma;
Keratosis, Seborrheic;
Melanoma;
Nevus
- From:Korean Journal of Dermatology
1987;25(1):64-70
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Sixty cutaneous tumors of different types were investigated by means of immunoperoxidase technique(avidin-biotm-peroxidase complex method) with the use of antikeratin antibody. The results were as follows: 1. Squamous cell carcinomas, keratoacanthomas, and Bowen's disease exhibited strong reactivity with antikeratin antibody. 2. In squamous cell carcinomas and keratoacanthomas, the most heaviest staining patterns were detected in areas of keratinization and horn pearl formation. 3. Basal cell carcinomas and seborrheic keratosis were moderately stained, whereas Paget'a disease and metastatic carcinoma(oat cell carcinoma) did not contain keratin. 4. In some cases of basal cell carcinomas, the tumor cells were partially positive. 5. Malignant melanomas, nevi, malignant.lymphomas, neural tumors, hemangiomas, and dermatofibromas were uniformly negative.
