Nell-1 in bone tissue engineering
10.3969/j.issn.2095-4344.2546
- Author:
Liang Yu JIN
1
Author Information
1. Harbin Medical University
- Publication Type:Journal Article
- Keywords:
Bone marrow mesenchymal stem cells;
Bone morphogenetic protein;
Bone regeneration and repair;
Nell-1;
Osteoporosis;
Regulatory factor;
Signaling pathway;
Synergistic effect
- From:
Chinese Journal of Tissue Engineering Research
2020;24(20):3217-3225
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND: Nel-like type 1 molecule (Nell-1) is a secreted glycoprotein that has been proven both in vitro and in vivo to be a potent osteoinductive factor that effectively promotes bone growth. Furthermore, it has been shown to repress adipogenic differentiation and inflammation. OBJECTIVE: To review the current research progress of Nell-1 in bone tissue engineering. METHODS: PubMed database was searched for relevant articles published from January 1996 to June 2019. Search words were “Nell-1; bone regeneration and repair; regulatory factor; signal path; bone morphogenetic protein; osteoporosis; marrow derived mesenchymal stem cells.” After removal of repetitive studies and inconsistent literature, 61 articles were finally analyzed. RESULTS AND CONCLUSION: Nell-1 has been proved to be a factor that can effectively promote bone tissue growth. Local application of Nell-1 has a good effect on the growth of long bone, spine and cartilage as well as cranial suture closure. Nell-1 is a new growth factor that has relatively simple bioeffects, so it has better biosafety and higher accuracy relative to the other bone growth factors. Nell-1 can synergize with other osteogenic factors such as bone morphogenetic proteins 2, 9. Nell-1 inhibits inflammatory reaction and lipogenesis induced by bone morphogenetic protein 2 and promotes osteogenesis. This provides a theoretical basis for the combination of Nell-1 and bone morphogenetic protein 2 to improve the clinical safety and efficacy in bone regeneration.
