A Case of Generalized Cranuloma Annulare Treated with Dapsone.
- Author:
Soo Chan KANG
;
Kyung Jae CHUNG
;
Jae Bok JUN
;
Soon Bong SUH
- Publication Type:Case Report
- Keywords:
Granuloma annulare;
Generalized;
Dapsone
- MeSH:
Dapsone*;
Female;
Granuloma Annulare;
Humans;
Middle Aged
- From:Korean Journal of Dermatology
1987;25(1):98-102
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Generalized granuloma annulare is manifested by numerous, symrnetrical, shiny, normal-skin colored, discrete or confluent, papular eruption on the sunexposed areas, mostly in females of past middle age. Up to date, a variety of therapeutic approaches have been tried with inconsistent results. Recently several agents have been reported to be inconsistent results. Recently several agents have reported to be effective in the treatment of genealizecl granuloma annulare. Of these, dapsone has been used with favorable respones. The fact dapsone can inhibit the lysosomal enzyme release and the mononuclear cell-rnediated rnyeloperoxidase cytotaxicity would account for its effect in granuloma annulare even in part. We observed a case of generalized granulare in a 49-year old man, who had had numerous normal-skin colored or faintly violaceous, flattopped papular eruption on the sun-exposed areas for 3 years. He was treated successfully with dapsone 100mg a day for about 22 months.
