Concept, mechanism and problem of gene therapy for osteoarthritis
10.3969/j.issn.2095-4344.2717
- Author:
Zhongling HU
1
Author Information
1. Department of Orthopedics, Affiliated Hospital, North China University of Science and Technology
- Publication Type:Journal Article
- Keywords:
Gene therapy;
Growth factor;
MiRNA;
Osteoarthritis;
Viral vector
- From:
Chinese Journal of Tissue Engineering Research
2020;24(27):4356-4363
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND: Specific gene expression at specific injury sites enhances cell regeneration. OBJECTIVE: To summarize the concept of gene therapy, to review the strategies of gene therapy and the mechanism of gene therapy for osteoarthritis, and to introduce the research direction of gene therapy. METHODS: Extensive consulted the literature on osteoarthritis gene therapy and related content in foreign databases such as PubMed and Science Direct. The key words were “Gene therapy, Cartilage, Cartilage repair, Osteoarthritis, Expression vectors, miRNA”. Above data were analyzed and summarized. RESULTS AND CONCLUSION: Gene therapy for osteoarthritis can be applied to all aspects of the pathogenesis of osteoarthritis and affect the metabolism of related substances. The target gene is delivered to the target cells through viral or non-viral vectors. At present, the focus of gene therapy is to accelerate cell repair and reduce inflammatory response. At the same time, multiple choices of gene vectors and target genes provide better individualized treatment options. The specific mechanism of gene therapy for osteoarthritis in clinic is not clear, and there is the possibility of gene mutation, which needs to be further studied to verify the safety.
