Wnt/beta-catenin signaling pathway in the treatment of osteoarthritis: New advances and application prospects
10.3969/j.issn.2095-4344.2714
- Author:
Tao BEI
1
Author Information
1. Department of Traumatic Orthopaedics and Hand Surgery, The First Affiliated Hospital of Guangxi Medical University
- Publication Type:Journal Article
- Keywords:
Cartilage;
Osteoarthritis;
Signaling pathway;
Wnt/β-catenin
- From:
Chinese Journal of Tissue Engineering Research
2020;24(29):4724-4730
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND: Wnt/β-catenin signaling pathway plays a vital role in the development of osteoarthritis. OBJECTIVE: To review the recent progress of treating osteoarthritis based on the Wnt/β-catenin signaling pathway. METHODS: An electronical literature retrieval of PubMed, CNKI and WanFang databases was performed to search the literatures concerning the Wnt/β-catenin pathway in the treatment of osteoarthritis. The keywords were “catenin; wnt; osteoarthritis; arthritis; degenerative; arthritides; deformans; pathway; wnt signaling; signaling pathway; wnt signaling pathways; wnt beta catenin signaling pathway; canonical wnt pathway; canonical wnt” in English and Chinese, respectively. Finally, 74 articles were included in result analysis. RESULTS AND CONCLUSION: The potential treatments of osteoarthritis based on the Wnt/β-Catenin signal pathway include natural antagonists, small molecule inhibitors, agonists, traditional Chinese medicine and drug reposition. These drug pathways provide chondroprotective effect via activating or inhibiting the Wnt/β-catenin signaling pathway. The treatment of osteoarthritis based on the Wnt/β-catenin signaling pathway is currently in the laboratory stage, but it has a great application prospect. How to accurately regulate the pathway and better transfer the research results into the application will become a hotspot in the future.
