Adding hormone in cocktail promotes rapid recovery after unicompartmental knee arthroplasty
10.3969/j.issn.2095-4344.2757
- Author:
Ju An YUE
1
Author Information
1. Department of Joint Surgery, Aviation General Hospital
- Publication Type:Journal Article
- Keywords:
Cocktail;
Fentanyl;
Multimodal;
Osteoarthritis;
Range of motion;
Rapid recovery;
Triamcinolone acetonide;
Unicompartmental knee arthroplasty
- From:
Chinese Journal of Tissue Engineering Research
2020;24(27):4343-4348
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND: Postoperative pain is a common clinical problem in unicompartmental knee arthroplasty, and severe pain can affect postoperative efficacy. Hormone is a common and effective anti-inflammatory drug, and there is some controversy over whether to add hormone to the local injection of cocktail in unicompartmental knee arthroplasty. OBJECTIVE: To evaluate the effectiveness of adding hormones to the cocktail to promote rapid recovery after unicompartmental knee arthroplasty. METHODS: Osteoarthritis patients receiving unilateral unicompartmental knee arthroplasty from October 2017 to March 2019 were randomly divided into a hormone group (local injection of cocktail + 40 mg triamcinolone acetonide) and a control group (local injection of cocktail + equivalent normal saline). Visual analogue scale score, fentanyl consumption, knee function, inflammatory indicators, adverse reactions and complications were observed in both groups after surgery. RESULTS AND CONCLUSION: (1) Finally, 80 patients were included in the study (n=40 in each group). There was comparability between the two groups (P > 0.05). (2) The static and dynamic visual analogue scale scores of patients in the hormone group at 1, 2 and 3 days after surgery were significantly lower than those in the control group (P < 0.05). (3) The dosage of fentanyl in the hormone group was significantly lower than that in the control group at 48 hours after surgery (P < 0.05). (4) At 1, 3, 5 days and 3 months after surgery, the knee flexion range of motion in the hormone group was higher than that of the control group (P < 0.05). (5) Hospital for Special Surgery score of knee in the hormone group was higher than that in the control group at 3 months after surgery (P < 0.05). There was no statistically significant difference in Hospital for Special Surgery scores of the knee between two groups at 6 months after surgery (P > 0.05). (6) C-reactive protein levels at 3 days and interleukin-6 levels at 24 hours after surgery in the hormone group were significantly lower than those in the control group (P < 0.05). (7) The incidence of complications in the hormone group was significantly lower than that in the control group (P < 0.05). (8) Addition of hormones in the cocktail can effectively promote the rapid recovery after unicompartmental knee arthroplasty..
