Research progress of circular RNAs in osteoarthritis: From known to unknown
10.3969/j.issn.2095-4344.3070
- Author:
Yiyang XU
1
Author Information
1. Department of Joint Surgery, First Affiliated Hospital of Sun Yat-sen University
- Publication Type:Journal Article
- Keywords:
Bone;
Cartilage;
Circular RNA;
Joint;
Mesenchymal stem cell;
Osteoarthritis;
Review;
Stem cell
- From:
Chinese Journal of Tissue Engineering Research
2021;25(10):1592-1598
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND: Circular RNA is the most concerned star molecules in the field of epigenetics in recent years, and has been proven to have such characteristics as universality, evolutionary conservatism, structural stability, tissue specificity and functional diversity. With the development of basic research on osteoarthritis, various kinds of mechanisms have been revealed, in which circular RNAs play an important role. OBJECTIVE: To summarize the progress of circular RNAs in the research of osteoarthritis, including the regulation of inflammation, the senescence and apoptosis of chondrocytes, the change of extracellular matrix components and the mediation of mechanical stress stimulation. METHODS: The first author used computers to retrieve PubMed, Web of Science, and Medline. English retrieval words were “circular RNA, osteoarthritis, cartilage, chondrocyte”. The retrieval period was from March 2015 to March 2020. RESULTS AND CONCLUSION: (1) It is suggested that circular RNA is a pivotal link in the occurrence and progression of osteoarthritis, and can be used as diagnostic markers and biological therapeutic targets. (2) In addition, current studies are limited to circular RNA sponging, articular cartilage degeneration and repair, while other functional mechanisms and the chondrogenic differentiation in mesenchymal stem cells are still unknown. These may be the direction in which basic research will translate into clinical outcomes in the future.
