Effects and mechanisms of enamel matrix derivatives on osteogenic differentiation of bone marrow mesenchymal stem cells
10.3969/j.issn.2095-4344.2187
- Author:
Meng MAOHUA
1
Author Information
1. School of Stomatology, Guizhou Medical University/Affiliated Stomatological Hospital, Guizhou Medical University
- Publication Type:Journal Article
- Keywords:
Bone defects;
Bone marrow mesenchymal stem cells;
Bone tissue engineering;
Cell sheet;
Enamel matrix derivatives;
Osteogenic differentiation;
Review;
Stem cells
- From:
Chinese Journal of Tissue Engineering Research
2021;25(13):2108-2113
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND: Bone marrow mesenchymal stem cells have good potential for directional differentiation, but the effect and mechanism of enamel matrix derivatives on osteogenic differentiation are still unclear. OBJECTIVE: To summarize the latest research progress on osteogenic induction of bone marrow mesenchymal stem cells by enamel matrix derivatives. METHODS: Related literature from 2000 to 2020 was searched in CNKI, Wanfang Data, VIP Database, PubMed databases. The key words are “Emdogain® or enamel matrix derivatives, bone marrow mesenchymal stem cells”. The languages of the literature were set to Chinese and English. When retrieving some classic articles, the publication date could be extended appropriately. Finally, 62 English articles and 5 Chinese articles meeting the inclusion criteria were selected. RESULTS AND CONCLUSION: There are different reports on the osteogenic effect of enamel matrix derivatives on bone marrow mesenchymal stem cells. Enamel matrix derivatives may enhance the osteogenic induction ability of bone marrow mesenchymal stem cells, and may enhance the osteogenic effect by affecting cells or cell membranes, but the relevant mechanism is unclear.
