Lymphatic vasculature in tumor metastasis and immunobiology

Author: Xinguo JIANG ¹
Author Information

1. VA Palo Alto Health Care System, Stanford University School of Medicine
Publication Type:Journal Article
Keywords: Cancer; Immunotherapy; Lymphatic; Lymphatic endothelial cell (LEC); Metastasis; R730.2
From: Journal of Zhejiang University. Science. B 2020;21(1):3-11
CountryChina
Language:English
Abstract: Lymphatic vessels are essential for tissue fluid homeostasis, immune cell trafficking, and intestinal lipid absorption. The lymphatics have long been recognized to serve as conduits for distant tumor dissemination. However, recent findings suggest that the regional lymphatic vasculature also shapes the immune microenvironment of the tumor mass and potentiates immunotherapy. This review discusses the role of lymphatic vessels in tumor metastasis and tumor immunity.