Induction of thoracic aortic dissection: a mini-review of β-aminopropionitrile-related mouse models
- VernacularTitle: β-氨基丙腈相关的小鼠胸主动脉夹层模型的综述
- Author:
Hai-qiong ZHENG
1
Author Information
- Publication Type:Journal Article
- Keywords: Angiotensin II (AngII); Hypertension; Mouse model; R543.1; Thoracic aortic dissection (TAD); β-Aminopropionitrile (BAPN)
- From: Journal of Zhejiang University. Science. B 2020;21(8):603-610
- CountryChina
- Language:English
- Abstract: Thoracic aortic dissection (TAD) is one of the most lethal aortic diseases due to its acute onset, rapid progress, and high rate of aortic rupture. The pathogenesis of TAD is not completely understood. In this mini-review, we introduce three emerging experimental mouse TAD models using β-aminopropionitrile (BAPN) alone, BAPN for a prolonged duration (four weeks) and then with added infusion of angiotensin II (AngII), or co-administration of BAPN and AngII chronically. We aim to provide insights into appropriate application of these three mouse models, thereby enhancing the understanding of the molecular mechanisms of TAD.
