Immunohistochemical Study of GLI-1 Expression in the Basal Cell Carcinoma of Sun-Exposed and Non-Exposed Areas.
- Author:
Young Ju SEO
1
;
Chul Woo KIM
;
Kwang Ho KIM
;
Kwang Joong KIM
;
Hye Rim PARK
;
Yong Sun KIM
Author Information
1. Department of Dermatology, College of Medicine, Hallym University, Anyang, Korea. kredos@snu.md
- Publication Type:Original Article
- Keywords:
Basal cell carcinoma;
GLI-1
- MeSH:
Carcinoma, Basal Cell*;
Humans;
Incidence;
Oncogenes;
Skin;
Transcriptional Activation;
Western World
- From:Korean Journal of Dermatology
2005;43(2):177-183
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Basal cell carcinoma (BCC) is the most prevalent cancer in the western world, showing a rapid increase in incidence. Activation of the Sonic hedgehog/Patched (PTCH) and is sisnalling pathway, due to PTCH inactivation, is a key event in sporadic and familial BCC development in humans and is associated with transcriptional activation of specific target genes, including GLI-1. Recently, PTCH inactivation by UV-specific mutation has been reported to develop BCC. OBJECTIVE: To evaluate the expression pattern of GLI-1 oncogene in BCC of sun-exposed and non-exposed areas of skin. METHOD: We examined 20 cases of BCC, and 4 cases of BCC occurring in sun-exposed and non-exposed areas, using an immunohistochemical method with paraffin-embedded sections. RESULTS: The results were as follows. 1. All cases of BCC showed a positive staining for GLI-1 protein. 2. In the staining pattern of GLI-1 protein, BCC in both sun-exposed and non-exposed areas showed diffuse staining throughout the tumor lobules. Moreover, the degree of staining was not found to be different between the BCC of sun-exposed and non-exposed areas. CONCLUSION: These results suggest that increased GLI-1 expression is important for BCC development. And multiple factors, including PTCH mutation due to UV irradiation, may affect GLI-1 expression.
