Carboxymethyl Bletilla striata polysaccharide-chitosan@curcumin polyelectrolyte complex films: Preparation and characterization
10.7501/j.issn.0253-2670.2020.04.023
- Author:
Yu-Rong WANG
1
Author Information
1. Shaanxi University of Chinese Medicine
- Publication Type:Journal Article
- Keywords:
Bletilla striata polysaccharide;
Carboxymethylation;
Chitosan;
Curcumin;
Formulation optimization;
Orthogonal design;
Polyelectrolyte complex films;
Quality evaluation;
Solvent evaporation method
- From:
Chinese Traditional and Herbal Drugs
2020;51(4):978-985
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To prepare carboxymethyl Bletilla striata polysaccharide-chitosan@curcumin (CM-BSP) polyelectrolyte complex films, optimize their preparation technology, and evaluate its quality. Methods: CM-BSP was synthesized, then CM-BSP and CS formed water-insoluble complex by electrostatic bonding, the Cur-loaded polyelectrolyte complex films were prepared by a volatilization of solvent method. The formulation and preparation technology were optimized using an orthogonal design method and the morphology and structure were observed by scanning electron microscopy and fourier transform microscopic infrared spectroscopy. Results: The optimal prescription was of CM-BSP 117 mg, CS 233 mg, glycerol 25%, Cur 20 mg. The mean thickness of Cur-loaded polyelectrolyte complex films was (74.0 ± 2.0) μm, drug loading capacities was 95.41%, and in vitro release rate was 93.78%. Conclusion: The obtained polyelectrolyte complex films displayed an smooth exterior inspection, uniform distribution, good drug loading capacities and in vitro release rate.
