Studies on chemical constituents of Chloranthus fortunei
10.7501/j.issn.0253-2670.2020.06.015
- Author:
Fang-You CHEN
1
Author Information
1. School of Pharmacy, Jiangxi University of Traditional Chinese Medicine
- Publication Type:Journal Article
- Keywords:
2’-hydroxy-4,3’,4’,6’-tetramethoxychalcone;
Antitumor activities;
Chloranthus fortune (A. Gray) Solms -Laub;
Friedelin;
Isovanillic acid;
Scopolin;
Shikimic acid
- From:
Chinese Traditional and Herbal Drugs
2020;51(6):1485-1490
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the antitumor constituents from Chloranthus fortunei. Methods: Various chromatographic techniques and spectroscopic methods were applied to investigate the chemical constituents from C. fortunei, and some of the compounds were screened for their antitumor activities by MTT method. Results: Sixteen compounds were obtained from the whole plants of C. fortunei and identified as rosmarinic acid (1), 2’-hydroxy-4,3’,4’,6’-tetramethoxychalcone (2), flavokawain A (3), cycloshizukaol A (4), atractylenolide III (5), 4β-hydroxy-8,12-epoxyeudesma-7,11-diene-1,6-dione (6), (8α)-6,8-dihydroxycadina-7 (11),10 (15)-dien-12-oic acid γ-lactone (7), curcolonol (8), 11-hydroxyldrim-8,12-en-14-oic acid (9), friedelin (10), isovanillic acid (11), 6β-hydroxystigmast-4-en-3-one (12), 3,4-dihydroxybenzoic acid (13), shikimic acid (14), scopolin (15) and N-acetyltyramine 1-O-β-D-glucoside (16). Compounds 4 and 5 showed weak cytotoxicity with IC50 ranged from 46 to 85 μmol/L. Conclusion: Compounds 2, 10, 11, and 13-15 are obtained from the genus Chloranthus for the first time and compounds 1-3 and 6-16 are isolated from C. fortunei for the first time. Some sesquiterpenoids from C. fortunei exhibited weak antitumor activities.
