Heritability and linkage study on heart rates in a Mongolian population.
10.3858/emm.2008.40.5.558
- Author:
Bayasgalan GOMBOJAV
1
;
Hansoo PARK
;
Jong Il KIM
;
Young Seok JU
;
Joohon SUNG
;
Sung Il CHO
;
Mi Kyeong LEE
;
Heechoul OHRR
;
Janchiv RADNAABAZAR
;
Jeong Sun SEO
Author Information
1. Department of Public Health, The Graduate School, Yonsei University, Seoul, Korea.
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
cardiovascular diseases;
chromosome mapping;
genomics;
heart rate;
Mongolia
- MeSH:
Adolescent;
Adult;
Chromosome Mapping/*methods;
Female;
Genetics, Population;
Genome, Human/*genetics;
Genome-Wide Association Study/methods;
*Heart Rate;
Humans;
Linkage (Genetics);
Male;
Middle Aged;
Mongolia;
Quantitative Trait Loci/*genetics;
Young Adult
- From:Experimental & Molecular Medicine
2008;40(5):558-564
- CountryRepublic of Korea
- Language:English
-
Abstract:
Elevated heart rate has been proposed as an independent risk factor for cardiovascular diseases, but their interrelationships are not well understood. In this study, we performed a genome-wide linkage scan in 1,026 individuals (mean age 30.6 years, 54.5% women) from 73 extended families of Mongolia and determined quantitative trait loci that influence heart rate. The DNA samples were genotyped using deCODE 1,039 microsatellite markers for 3 cM density genome-wide linkage scan. Correlation analysis was carried out to evaluate the correlation of the covariates and the heart rate. T-tests of the heart rate were also performed on sex, smoking and alcohol intake. Consequently, this model was used in a nonparametric genome-wide linkage analysis using variance component model to create a multipoint logarithm of odds (LOD) score and a corresponding P value. In the adjusted model, the heritability of heart rate was estimated as 0.32 (P<.0001) and a maximum multipoint LOD score of 2.03 was observed in 77 cM region at chromosome 18. The second largest LOD score of 1.52 was seen on chromosome 5 at 216 cM. Genes located on the specified locations in chromosomes 5 and 18 may be involved in the regulation of heart rate.
