Prediction and analysis of quality markers between crude and wine-processed Scutellaria baicalensis based on "components-targets-metabolism" network analysis
10.7501/j.issn.0253-2670.2020.10.004
- VernacularTitle: 基于"成分-靶点-代谢"预测分析黄芩酒炙前后质量标志物
- Author:
Lian-Qi HU
1
Author Information
1. Jiangxi University of Traditional Chinese Medicine
- Publication Type:Journal Article
- Keywords:
Baicalein;
Baicalin;
Network pharmacology;
Oroxylin A-7-O-glucuronide;
Quality markers;
Scutellaria baicalensis Georgi;
Wine-processed;
Wogonin
- From:
Chinese Traditional and Herbal Drugs
2020;51(10):2618-2626
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the potential Q-markers between crude Scutellaria baicalensis (CSR) and wine-processed S. baicalensis (WSR) based on "components-targets-metabolism" network analysis. Methods: According to the differential components between CSR and WSR, the network relationship of "components-target-metabolomics" was constructed combining network pharmacology and metabolomics. The correlation analysis was then conducted between flavonoids glycosides, and aglycones in S. baicalensis, between differential components and endogenous metabolites to predict the potential quality markers. Results: In this study, combining the results of network pharmacology and metabolomics, baicalin and oroxylin A-7-O-glucuronide were regarded as the quality markers of CSR; Baicalein and wogonin were considered as the quality markers of WSR. Conclusion: It is crucial wine-processed mechanism of S. baicalensis that glutinous rice wine can promote the dissolution and absorption of aglycones. Overall, identification of the differences between Chinese herbal decoction pieces and it processed product, combining analysis of network pharmacology and metabolomics, which provides a demonstration for the investigation of quality markers of Chinese herbal pieces.
