Chemical constituents of ethyl acetate extracts from root bark of Celastrus monospermus
10.7501/j.issn.0253-2670.2020.11.006
- VernacularTitle: 独子藤根皮醋酸乙酯部位的化学成分研究
- Author:
Ming-Xiang CHEN
1
Author Information
1. School of Pharmacy, Guangdong Medical University
- Publication Type:Journal Article
- Keywords:
2α,3β,19α,23-tetrahydroxyolean-12-en-28-oic acid;
4-hydroxy-3-methoxybenzoic acid;
Celastrus monospermus Roxb.;
Ethyl acetate extract;
Polpunonic acid
- From:
Chinese Traditional and Herbal Drugs
2020;51(11):2895-2899
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the chemical constituents of ethyl acetate extracts from the root bark of Celastrusmonospermus. Methods: The compounds were separated and purified by repeated column chromatographic methods including silica gel, ODS and Sephadex LH-20, and the chemical structures of compounds were determined by spectral data analyses. Results: Twelve compounds were obtained and identified as polpunonic acid (1), p-hydroxybenzoic acid (2), 4-hydroxy-3-methoxybenzoic acid (3), salaspermic acid (4), 3-oxo-2β-hydroxyfriedelan-29-oic acid (5), celastrol (6), 3α,22β-dihydroxy-olean-12-en-29-oic acid (7), orthosphenic acid (8), 21-oxo-2α,3α,22β-trihydroxy-29-nor-friedelan-24,2â-lactone (9), 2,3-dioxo-6α,10-dihydroxy-24-nor-friedelan-4,7-dien-29-oic acid (10), 2α,3β,19α,23-tetrahydroxyolean-12-en-28-oic acid (11) and 2α,3β-dihydroxyolean-12-en-23,28,30-trioic acid (12). Conclusion: Compounds 1, 3, 7, 10-12are obtained from this plant for the first time, and compounds 3, 11, 12 of them were separated from the genus Celastrus for the first time.
