Discussion and consideration on pharmacology and toxicology of Areca catechu and its rational application
10.7501/j.issn.0253-2670.2020.12.027
- VernacularTitle: 槟榔药理毒理探讨与合理用药思考
- Author:
An-Zheng NIE
1
Author Information
1. The First Affiliated Hospital of Zhengzhou University
- Publication Type:Journal Article
- Keywords:
Areca catechu L.;
Arecoline;
Oral cancer;
Rational drug uses;
Security
- From:
Chinese Traditional and Herbal Drugs
2020;51(12):3329-3336
- CountryChina
- Language:Chinese
-
Abstract:
Areca catechu ranks the first of China's precious "four southern medicines", with a history of more than 1 800 years of medicinal use and extensive clinical application. The pharmacological effects of A. catechu mainly focus on insect repellent, anti-tumor, anti-aging, anti-atherosclerosis and the effects on digestive system and nervous system. In recent years, safety problems such as oral cancer caused by consumption of A. catechu have been frequently reported, and the main chemical components of both medicinal and edible A. catechu are arecoline, so the clinical safety of medicinal A. catechu has been questioned. Based on the chemical composition, this paper analyzes the pharmacological and toxicological characteristics of A. catechu, discusses the points for attention in clinical application, in order to provide a reference basis for the clinical safe and rational use of A. catechu.
