Meta-analysis on effect of Kushen Gel on high-risk cervical HPV infection
10.7501/j.issn.0253-2670.2020.12.019
- VernacularTitle: 苦参凝胶治疗宫颈高危型人乳头瘤病毒感染的Meta分析
- Author:
Cai-Miao YIN
1
Author Information
1. Affiliated Hospital of Chengdu University of Traditional Chinese Medicine
- Publication Type:Journal Article
- Keywords:
Cervical cancer;
Cervical high-risk human papillomavirus infection;
Cervical intraepithelial neoplasia;
Kushen Gel;
Meta-analysis
- From:
Chinese Traditional and Herbal Drugs
2020;51(12):3268-3273
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To systematically evaluate the effectiveness of Kushen Gel in the treatment of cervical high-risk human papillomavirus (HR-HPV) infection. Methods: The Cochrane Library, PubMed, Embase, Medline, Wanfang, VIP, CNKI, and CBM databases were electronically searched to collect randomized controlled trials (RCTs) on Kushen Gel in the treatment of the cervical high-risk HPV infection from their inception to December 2019. Two researchers screened the articles, extracted the data, assessed the risk of bias of the eligble studies independently, and performed Meta-analysis with RevMan 5.3. Results: A total of 583 cases were included in five RCTs. The Meta-analysis showed that HR-HPV negative rate [RR = 1.38, 95% CI(1.20, 1.58), P < 0.000 01], reduction of HPV-DNA virus load [MD = -0.70, 95% CI (-0.85, -0.56), P < 0.000 01], and the reduction of postoperative complication rate [RR = 0.45, 95% CI (0.32, 0.65), P < 0.000 1] of applying Kushen Gel alone or applying Kushen Gel combined with microwave/LEEP therapy in the treatment of cervical HR-HPV infection or combined with cervical intraepithelial neoplasia (CIN) were significantly higher than those in the follow-up group; The HR-HPV negative rate of Kushen Gel was higher than interferon group (P < 0.05); There was no significant difference in the one year recurrence rate after LEEP combined with Kushen Gel in the treatment of cervical HR-HPV infection combined with CIN2/CIN3 compared with the follow-up control group (P > 0.05). Conclusion: The therapeutic effect of applying Kushen Gel can increase the rate of clearance of HPV, reduce HPV-DNA load, and reduce postoperative complication. There is no evidence that the use of Kushen Gel after LEEP can reduce the recurrence rate of CIN2/CIN3. Due to the limitation of the quantity and quality of the included studies, the results need to be further verified and updated by more high-quality RCTs.
