Application of multi-omics in toxicity and detoxification of Chinese materia medica
10.7501/j.issn.0253-2670.2020.12.001
- VernacularTitle: 多组学技术在中药毒性及解毒研究中的应用
- Author:
Qiong MAN
1
Author Information
1. College of Pharmacy, Gansu College of Traditional Chinese Medicine
- Publication Type:Journal Article
- Keywords:
Chinese materia medica;
Detoxification;
Metabolomics;
Multi-omics;
Proteomics;
Toxicity
- From:
Chinese Traditional and Herbal Drugs
2020;51(12):3117-3125
- CountryChina
- Language:Chinese
-
Abstract:
The rapid development of systems biology provides ideas and means for the in-depth study of Chinese materia medica (CMM). It can comprehensively and systematically analyze the molecular mechanism of CMM and Chinese medicine prescription in treating diseases with multi-component and multi-target. It has become the direction and hot spot of the safety research on the toxicity and detoxification of CMM based on the integrated multi-omics strategy. In this paper, the ideas, methods and progress of genomics, transcriptomics, proteomics, metabonomics and multi-omics integration technology in the study of toxicity, detoxification and mechanism of CMM were reviewed, which provides reference for the in-depth study of multi-omics technology in toxicity and detoxification of CMM.
