Research progress on sedative and hypnotic effect of Sini Powder and strategic analysis of its new drug development
10.7501/j.issn.0253-2670.2020.13.028
- VernacularTitle: 四逆散镇静催眠作用研究进展及其新药开发的策略分析
- Author:
Yu-Gui ZHANG
1
Author Information
1. Gansu University of Chinese Medicine
- Publication Type:Journal Article
- Keywords:
New traditional Chinese medicine;
Post-traumatic stress disorder;
Research and development strategy;
Sedation and hypnosis;
Sini Powder
- From:
Chinese Traditional and Herbal Drugs
2020;51(13):3575-3584
- CountryChina
- Language:Chinese
-
Abstract:
Sini Powder is the traditional Chinese medicine compound, which comes from Treatise on Febrile Diseases. It is used to treat the syndrome of yang depression and reversal cold of limbs. Sini Powder has a certain effect on treating insomnia caused by liver depression and spleen deficiency. Lots of researches have shown that Sini Powder has a sedative and hypnotic effect similar to diazepam and plays an important role in improving sleep disorders caused by post-traumatic stress disorder (PTSD). Sini Powder is not included in Chinese Pharmacopoeia (2015 edition). It is probably to develop Sini Powder into a new drug for the clinic. We collated and summarized the literature about the sedative and hypnotic effect and the improvement of sleep disorders caused by PTSD of Sini Powder. Based on the modern research on the sedative and hypnotic effect of Sini Powder, we think the effect of "relieve uneasiness of mind and body tranquilization" adapts the theory of traditional Chinese medicine, so that it can improve the applied range of Sini Powder. Meanwhile, we analyzed the possibility of Sini Powder being selected into the ancient classical prescription and key problem in research and development on drug preparation of Sini Powder according to regulations of traditional Chinese medicine. Then we put forward some suggestions for further research from two aspects which are the development of Sini Powder and new drugs of traditional Chinese medicine, to provide a reference for the development of new Chinese medicine preparation of Sini Powder focus on "expelling pathogen and relieving depression, soothing liver and regulating spleen, tranquilizing mind".
