Effect of ophiopogonin D on serum lipids and intestinal flora in ApoE-/- mice with high-fat diet
10.7501/j.issn.0253-2670.2020.13.018
- VernacularTitle: 麦冬皂苷D对高脂饲养ApoE-/-小鼠血脂及肠道菌群的影响
- Author:
Yi-Hao CHEN
1
Author Information
1. College of Traditional Chinese Medicine, Southern Medical University
- Publication Type:Journal Article
- Keywords:
Blood lipid level;
Hepatic steatosis;
Intestinal flora;
Obesity;
Ophiopogonin D;
Total cholesterol;
Triglyceride
- From:
Chinese Traditional and Herbal Drugs
2020;51(13):3501-3508
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the effect of ophiopogonin D (OP-D) on blood lipids and intestinal flora in ApoE-/- mice fed with high-fat diet (HFD). Methods: A total of 24 male ApoE-/- mice, aged six weeks old, were randomly divided into control group, model group, OP-D group [0.5 mg/(kg∙d)] and simvastatin group [5 mg/(kg∙d)]. Another six male C57BL/6 mice were in blank group. After 12 weeks of HFD, the drugs were given by intragastric administration for 12 weeks. After the end of administration, fresh feces of mice were collected to detect intestinal flora. Serum of mice was separated to detect blood lipid. Liver section staining was prepared to observe the damage. Results: OP-D could reduce the weight gain of mice caused by HFD, inhibit the increase of total cholesterol and triglyceride, improve hepatic steatosis, and regulate intestinal flora imbalance. Conclusion: OP-D may regulate blood lipids and hepatic steatosis by improving intestinal flora imbalance induced by HFD in ApoE-/- mice.
