Effect of influencing factors on stability of Guanxinning Injection
10.7501/j.issn.0253-2670.2020.14.011
- VernacularTitle: 冠心宁注射液稳定性影响因素研究
- Author:
Yi-Fan CUI
1
Author Information
1. Modern Research Center for Traditional Chinese Medicine of Shanxi University
- Publication Type:Journal Article
- Keywords:
5-hydroxymethylfurfural;
Caffeic acid;
Chlorogenic acid;
Danshensu;
Ferulic acid;
Fingerprint;
Guanxinning Injection;
Principal component analysis;
Protocatechuic aldehyde;
Rosmarinic acid;
Salvianolic acid B;
Senkyunolide;
Stability;
Vanillin acid;
Vanillin aldehyde
- From:
Chinese Traditional and Herbal Drugs
2020;51(14):3686-3692
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To identify the influencing factors (light, temperature, etc) of Guanxinning Injection (GXNI) in the storage and transportation process, and lay the foundation for the storage and transportation of GXNI. Methods: Taking the content of sodium danshensu, protocatechuic aldehyde, ferulic acid, rosmarinic acid, and salvianolic acid B as quantitative indicators, combined with the common peak similarity analysis, principal component analysis, and relative content comparison in the fingerprint to evaluate the effect of different influencing factors on the main chemical composition of GXNI. Results: After low temperature treatment, the content of four compounds, such as senkyunolide I and senkyunolide H, were increased, the content of five compounds, such as vanillic acid and vanillin aldehyde, were reduced, the content of 13 compounds, such as protocatechuic aldehyde and ferulic acid, showed no significant changes. Under the freezing-thawing conditions, the content of four compounds, such as 5-hydroxymethylfurfural, were increased, the content of seven compounds, such as vanillin acid and chlorogenic acid, was reduced, the content of 11 compounds, such as sodium danshensu and ferulic acid, showed no significant changes. Under high temperature, the content of seven compounds, such as sodium danshensu and protocatechuic aldehyde, were increased, the content of 11 compounds, such as ferulic acid and rosmarinic acid, were reduced, the content of four compounds, such as chlorogenic acid and caffeic acid, showed no significant changes. Under strong light conditions, the content of two compounds, such as senkyunolide H, were increased, the content of 16 compounds, such as ferulic acid and salvianolic acid B, were reduced, the content of four compounds, such as sodium danshensu and protocatechuic aldehyde, showed no significant changes. Conclusion: High temperature and strong light will affect the components of GXNI, and some compounds will also be affected under freezing-thawing conditions. Thus, the GXNI should be stored under low temperature, but higher than 0 ℃.
