AnewlignanfromstemsofTrigonostemonlutescens
10.7501/j.issn.0253-2670.2020.14.004
- VernacularTitle: 黄花三宝木茎中1个新颖木脂素类化合物
- Author:
Da-Peng ZHANG
1
Author Information
1. School of Life Science and Technology, Xinjiang University
- Publication Type:Journal Article
- Keywords:
5,5'-dimethoxylclemaphenol A;
Clemaphenol A;
Cytotoxic activity;
Lirioresinol B dimethyl ether;
Syringaresinol;
TrigonostemonlutescensY. T. Chang et J. Y. Liang
- From:
Chinese Traditional and Herbal Drugs
2020;51(14):3633-3636
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the chemical constituents in the stems of Trigonostemonlutescens. Methods:Silica gel column chromatography and semi-preparative high performance liquid chromatography were used for separation and purification. The structures were identified by NMR, IR, MS and other spectral techniques. Toxicity of compounds 1-4 on human lung cancer A549 cells, cervical cancer Hela cells and breast cancer MCF-7 cells was determined by the MTT method. Results: Four lignans were isolated from the stems of T. lutescens. The structures were identified as 5,5'-dimethoxylclemaphenol A (1), syringaresinol (2), lirioresinol B dimethyl ether (3) and clemaphenol A (4). Conclusion:Compound1 is a new compound, and compounds 2-4 are isolated from this genus for the first time. Compounds 1-4 have certain cytotoxic activity on A549, HeLa and MCF-7 human tumor cells.