Study on effect of compatibility on pharmacokinetics of Guizhi Zhumian prescription in cynomolgus monkeys based on Q-marker
10.7501/j.issn.0253-2670.2020.15.019
- VernacularTitle: 基于质量标志物Q-marker的桂栀助眠方在食蟹猴体内药动学研究
- Author:
Wei WEI
1
Author Information
1. Guangxi Key Laboratory of Efficacy Study on Chinese Materia Medica, Guangxi University of Chinese Medicine
- Publication Type:Journal Article
- Keywords:
4-methoxycinnamic acid;
Chlorogenic acid;
Cinnamic acid;
Cinnamon cassia Presl;
Compatibility;
Coumarin;
Cynomolgus monkey;
Gardeniae Fructus;
Gardenoside;
Genipin;
Geniposidic acid;
Guizhi Zhumian prescription;
Pharmacokinetics;
Q-marker;
T1/2;
Traditional Chinese medicine;
UPLC-MS/MS
- From:
Chinese Traditional and Herbal Drugs
2020;51(15):3996-4002
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the effect of compatibility on pharmacokinetics of the main components of Guizhi Zhumian prescription (GZP) based on the concept of Q-marker and to provide evidences for the determination of the Q-markers of this prescription. Methods: UPLC-MS/MS method was established for the study of the pharmacokinetics behaviors of seven main components, including cinnamic acid, 4-methoxycinnamic acid, coumarin, gardenoside, genipin, geniposidic acid, and chlorogenic acid, before and after the compatibility of GZP in plasma of cynomolgus monkeys. Results: Compared with the pharmacokinetics parameters of Cinnamomum cassia and Gardenia jasminoides, the AUC and Cmax of cinnamic acid, coumarin, geniposidic acid, and chlorogenic acid in GZP were increased obviously; The t1/2 of cinnamic acid, 4-methoxycinnamic acid, and coumarin were decreased; And the tmax of 4-methoxycinnamic acid, and geniposide were prolonged. Conclusion: Compatibility of GZP could significantly change the in vivo exposure status of the main components, and the seven main compounds were determined to be the Q-markers of GZP.
