Study on efficacy network and mechanism of Huobahuagen Tablets "treating different diseases with same method" for lupus erythematosus and rheumatoid arthritis
10.7501/j.issn.0253-2670.2020.16.016
- VernacularTitle: 火把花根片“异病同治”红斑狼疮和类风湿性关节炎的功效网络与机制探讨
- Author:
Jun-De GE
1
Author Information
1. The Second Hospital, Shandong University
- Publication Type:Journal Article
- Keywords:
Different disease treatment with same method;
Huobahuagen Tablets;
Lupus erythematosus;
Network pharmacology;
Rheumatoid arthritis
- From:
Chinese Traditional and Herbal Drugs
2020;51(16):4223-4235
- CountryChina
- Language:Chinese
-
Abstract:
Objective: Based on the network pharmacology research method, combined with the theory of traditional Chinese medicine, to explore the mechanism of the interaction of Huobahuagen Tablets (HBHGT) for treating different diseases with same method between the lupus erythematosus (LE) and rheumatoid arthritis (RA). Methods: The components in HBHGT and their targets were collected by using TCMSP, Chinese Herb Dictionary, and other databases in combination with literature. Disease-related targets for lupus erythematosus and rheumatoid arthritis were collected using databases such as CTD, PubMed, and Drugbank in conjunction with literature. The herb-ingredient-target network and drug-target-disease interaction PPI network were constructed by Cytoscape software, and the gene function and signaling pathway of the constructed network were analyzed. ClueGO plugin in Cytoscape software was used for GO analysis and Pathway analysis. Results: The main components of torch flower roots were epicatechin, triptolide and triptonide, and 138 key targets were obtained. Through GO analysis and Pathway analysis, it was found that HBHGT for treating different diseases with same method between the lupus erythematosus and rheumatoid arthritis involved 17 common targets such as EGFR, CRK, and LCK, and its mechanism may be related to biological processes such as phosphoprotein binding, ERBB2 signaling pathway, peptidyl tyrosine autophosphorylation, and receptor tyrosine kinase signaling pathway, FGFR3 signaling pathway, Fcε receptor (FCERI) signaling pathway and other pathways. Receptor tyrosine kinase signaling pathway was the main pathway of HBHGT for treating different diseases with same method. Conclusion: This study confirmed from the two aspects of target and pathway that HBHGTs had great similarities in the treatment of RA and LE. Among them, EGFR, CBL, LCK, and other targets and EGFR-related signaling pathways were the key targets and pathways of HBHGT for "different diseases with the same treatment".
