Studies on chemical constituents in Guizhi Fuling Capsule (VII)
10.7501/j.issn.0253-2670.2020.16.002
- VernacularTitle: 桂枝茯苓胶囊化学成分研究VII
- Author:
Hong-Da ZHANG
1
Author Information
1. Jiangsu Kanion Pharmaceutical Co., Ltd.
- Publication Type:Journal Article
- Keywords:
1'-O-galloylsucrose;
1,2,3,4,6-pentagalloylglucose;
3'-O-galloylsucrose;
3'-O-galloylsucrose;
Guizhi Fuling Capsule;
Screening
- From:
Chinese Traditional and Herbal Drugs
2020;51(16):4113-4116
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the chemical constituents from the n-butanol extract of Guizhi Fuling Capsule. Methods The chemical constituents were isolated and purified by multiple chromatographic methods. Their structures were identified on the basis of the spectral data and physicochemical properties. Results Five compounds were identified as 3'-O-galloylsucrose (1), 4'-O-galloylsucrose (2), 6'-O-galloylsucrose (3), 1'-O-galloylsucrose (4), and 1,2,3,4,6-pentagalloylglucose (5). Conclusion Compounds 1-5 are isolated from Guizhi Fuling Capsule for the first time, and compound 1 is a new compound. Compounds 1-5 inhibited calcium influx in uterine smooth muscle cells of primary mice.
