A new prenylated flavonoid glycoside from Sinopodophyllum hexandrum
10.7501/j.issn.0253-2670.2020.17.003
- VernacularTitle: 桃儿七中1个新的异戊烯基黄酮苷类化合物
- Author:
Yun-Ling XU
1
Author Information
1. Zhejiang Institute of Traditional Chinese Medicine
- Publication Type:Journal Article
- Keywords:
Acacetin;
Cytotoxic activities;
Diosmetin;
Prenylated flavonoid glycoside;
Sinoflavonoid glycosides A;
Sinopodophyllum hexandrum (Royle) Ying;
Sophoflavescenol
- From:
Chinese Traditional and Herbal Drugs
2020;51(17):4388-4392
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the chemical constituents from Sinopodophyllum hexandrum and their antitumor activities. Methods: The constituents were separated by chromatography of silica gel, ODS, Sephadex LH20 and pre-TLC. Their structures were elucidated by spectroscopic means. The in vitro cytotoxic activities of the isolated compounds were studied by MTT method. Results: Nine compounds were isolated and identified as 8,2'-diprenylquercetin 3-methyl ether-4'-O-β-D-glucoside (1), 8,2'-diprenyl quercetin-3- methylether (2), 5,7,4'-trihydroxy-3'-(3-methylbut-2-enyl)-3-methoxy flavone (3), 8-prenylkaempferol (4), sophoflavescenol (5), podoverine A (6), sinoflavonoid K (7), diosmetin (8) and acacetin (9). Conclusion: Compound 1 is a new compound named sinoflavonoid glycosides A, and compounds 5-9 are isolated from S. hexandrum for the first time. Compounds 1-5 show cytotoxicities against HeLa cells with IC50 of 42.6, 46.9, 26.9, 16.1 and 31.2 μmol/L, respectively.
