Research on compatibility rule of traditional Chinese medicine for treatment of hyperhomocysteinemia based on data mining
10.7501/j.issn.0253-2670.2020.18.015
- VernacularTitle: 基于数据挖掘技术研究中医药治疗高同型半胱氨酸血症的组方配伍规律
- Author:
Lan-Ping SUN
1
Author Information
1. College of Pharmacy, Gansu University of Chinese Medicine
- Publication Type:Journal Article
- Keywords:
Association rule;
Cluster analysis;
Data mining;
Formula rule;
Hyperhomocysteinemia;
TCMISS V 2.5
- From:
Chinese Traditional and Herbal Drugs
2020;51(18):4712-4718
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To summarize the medication rules of traditional Chinese medicine for treatment of hyperhomocysteinemia (HHcy) by data mining. Methods: To collect the relevant literatures of TCM treatment of HHcy from CNKI, VIP, Wanfang Data, CBM from the establishment of the database to December 31, 2019. TCMSS V 2.5 was used to count the frequency of medication, common drug pairs and drug combinations; Association rules, improved mutual information method, complex system entropy cluster analysis were used to analyze drug association rules and core drug combinations; Unsupervised entropy hierarchical clustering was used to analyze the new prescriptions. Results: There were 156 prescriptions with 199 Chinese medicinal herbs and 46 Chinese medicinal herbs of them with functions of promoting blood circulation and removing blood stasis, promoting urination and draining dampness, pacifying liver and extingushing wind and tonic deficiency were used for more than 10 times,. A total of 33 high-frequency drug combinations were obtained through data mining, and the top five combinations were Poria-Gastrodiae Rhizoma, Chuanxiong Rhizoma-Angelicae Sinensis Radix, Chuanxiong Rhizoma-Astragali Radix, Carthami Flos-Chuanxiong Rhizoma and Chuanxiong Rhizoma-Gastrodiae Rhizoma. A total of 20 core drug combinations and 10 potential new prescriptions were obtained through evolution. Conclusion: In the treatment of HHcy in TCM, blood-activating and stasis-resolving medicines, urination-promoting and dampness-draining medicines, liver-pacifying and wind-extingushing medicines and tonic deficiency medicines were mostly used. These prescriptions show that the main methods of promoting blood circulation and removing blood stasis, and resolving phlegm and turbidity, as well as supplementing qi and invigorating spleen, promoting urination and draining dampness, removing phlegm and widening chest reflect the characteristics of addressing both the symptoms and root causes of TCM.
